[Solution]Pharmacology

Section A You must answer all the questions in this section 1. Define ‘efficacy’. [2 marks] Using the term efficacy, explain the difference between inverse…

Section A
You must answer all the questions in this section
1. Define ‘efficacy’. [2 marks]

Using the term efficacy, explain the difference between inverse agonism and agonism. Summarise this in a diagram of a dose-response curve.

[8 marks]
3. Write a few sentences paraphrasing (in your own words) the aim of the
study written by Wisler et al.,2007.
[4 marks]

Draw at least one diagram to summarise the signalling pathways that mediate G-protein-dependent and -independent signalling of the B2- adrenergic receptor. [12 marks]
Explain why HEK293 cells were chosen for the experiments in the Wisler et al. study. [2 marks]
What roles do isoproterenol and propranolol play on the experiments of Wisler et al. 2007? [4 marks]
What is the role of the B2AR TYY mutant in the Wisler et al. study? Explain the meaning of figure 2 in your answer. [8 marks]
What is the role of the siRNA targeting B-arrestin 2 in the Wisler et al. study? Explain Fig 5 in your answer. [10 marks]
Summarise the mechanism of action of Carvedilol, use evidence drawn from the Wisler et al. study. [10 marks]

Total marks for section: 60
Section B

Give details of the mechanism of action of an inverse agonist of your choice used to treat disease. Describe the drug’s action on its receptor, downstream signalling events and evidence of link between the drug receptor and disease pathology.

Total marks for section: 40
 

The post Pharmacology

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